393 results found
    1. Cancer Biology

    Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

    Blake Ferguson et al.
    Genetic variation determines whether or not UV exposure accelerates melanoma development.
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson et al.
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Immunology and Inflammation

    Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

    Mark Austin Hanson et al.
    While antimicrobial cocktails are highly effective for defence against pathogenic microbes, the innate immune response may instead employ highly specific peptidic antibiotics to combat certain natural enemies.
    1. Neuroscience

    Dynamic control of hippocampal spatial coding resolution by local visual cues

    Romain Bourboulou et al.
    Hippocampal spatial coding resolution can quickly adapt to local visual cues within a given environment.
    1. Neuroscience

    Leave-One-Trial-Out, LOTO, a general approach to link single-trial parameters of cognitive models to neural data

    Sebastian Gluth, Nachshon Meiran
    Leave-One-Trial-Out (LOTO) is a general, efficient and easily implementable approach for inferring trial-by-trial measures of computational model parameters in order to link these measures to neural mechanisms.
    1. Computational and Systems Biology
    2. Neuroscience

    Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

    Michele N Insanally et al.
    During behavior, many neurons do not have classic trial-averaged responses to behaviorally relevant stimuli, but can still have activity and population dynamics related to stimulus and behavioral choice on single trials.
    1. Neuroscience

    Impaired voice processing in reward and salience circuits predicts social communication in children with autism

    Daniel Arthur Abrams et al.
    Children with autism often 'tune out' the voices in their environment and new results show that impaired processing of voices in the brain's reward system may underlie this social behavior.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell et al.
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.
    1. Neuroscience

    Emotional faces guide the eyes in the absence of awareness

    Petra Vetter et al.
    When emotional faces are rendered invisible, our eyes look towards fearful faces and away from angry faces.
    1. Evolutionary Biology
    2. Neuroscience

    Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis

    Ian F Miller et al.
    The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.

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