324 results found
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers et al.
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.
    1. Biochemistry and Chemical Biology

    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

    Tyler B Faust et al.
    The HIV-1 Tat protein hijacks host non-degradative ubiquitination to trigger the nuclear import of the transcription elongation factor, P-TEFb.
    1. Chromosomes and Gene Expression
    2. Developmental Biology and Stem Cells

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova et al.
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Neuroscience

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Neuroscience

    Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

    Maxime WC Rousseaux et al.
    Loss of a developmentally essential gene in adulthood is tolerated in mice, thus offering potential therapeutic options for Alzheimer's and Parkinson's disease.
    1. Immunology and Inflammation

    Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

    Jie Geng et al.
    HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
    1. Developmental Biology and Stem Cells
    2. Immunology and Inflammation

    Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

    Divyanshu Malhotra et al.
    A new form of chemokine signaling bias that depends on cell state is identified.
    1. Neuroscience

    Cognitive regulation alters social and dietary choice by changing attribute representations in domain-general and domain-specific brain circuits

    Anita Tusche, Cendri A Hutcherson
    Regulatory success operates by goal-consistent increases and decreases of distinct attribute representations in generic neural hubs and in domain-specific brain regions, explaining when and why regulatory success generalizes across domains and contexts.
    1. Neuroscience

    Differential temporal dynamics during visual imagery and perception

    Nadine Dijkstra et al.
    In contrast to perception, during visual imagery, there are no clear time-locked processing stages and imagery specifically overlaps with perceptual processing around 160 ms after stimulus onset and from 300 ms onwards.
    1. Computational and Systems Biology
    2. Neuroscience

    Post-decision biases reveal a self-consistency principle in perceptual inference

    Long Luu, Alan A Stocker
    Humans are biased in their assessment of sensory information by their own preceding categorical judgment in an attempt to remain self-consistent.

Refine your results by:

Type
Research categories