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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin et al.
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Immunology and Inflammation

    Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

    Bronwen R Burton et al.
    Investigation of antibody responses to variant Dengue virus proteins demonstrate new mechanisms that could increase the potential for vaccines to protect against mutable pathogens such as Flu, Dengue and HIV.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

    Yiska Weisblum et al.
    SARS-CoV-2 spike variants that resist neutralization by therapeutic antibodies or convalescent plasma can be generated in the laboratory and exist at low frequency in natural populations.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

    Yen-Li Li et al.
    To protect mammals against retroviral infections, TRIM5 restriction factors recognize viral capsids by forming complementary hexagonal nets that can adapt to the patterns of capsid protein subunits on the viral capsid surface.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis

    Romeo Papazyan et al.
    A previously unappreciated histone methylation pathway helps limit DNA double-strand break formation and recombination in heterochromatin during meiosis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Reconstitution reveals two paths of force transmission through the kinetochore

    Grace E Hamilton et al.
    Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.
    1. Medicine

    Lipocalin-2 is an anorexigenic signal in primates

    Peristera-Ioanna Petropoulou et al.
    Lipocalin-2 is a strong predictor of hunger scores, reflects an anti-obesity response that is deregulated in severely obese subjects, and exerts an anorexigenic function with a conserved interspecies mechanism.
    1. Microbiology and Infectious Disease

    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

    Shuxin Liu et al.
    A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott et al.
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Cell Biology
    2. Developmental Biology

    TMEM95 is a sperm membrane protein essential for mammalian fertilization

    Ismael Lamas-Toranzo et al.
    TMEM95, a protein localized to the sperm acrosome cap, is essential for fertilization.