98 results found
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide resource for the analysis of protein localisation in Drosophila

    Mihail Sarov et al.
    A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of Drosophila development.
    1. Developmental Biology

    A complex regulatory landscape involved in the development of mammalian external genitals

    Ana Rita Amândio et al.
    In vertebrates, large regulatory landscapes sometimes behave as coherent regulatory units, which may explain the lack of effect sometimes observed when single enhancer sequences are deleted in isolation.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

    Gizem Özbaykal et al.
    For initiation of cell-wall insertion, the cross-linking enzyme PBP2 stably binds to a component of the cell envelope that is different from MreB filaments.
    1. Developmental Biology

    Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

    Craig T Jacobs, Peng Huang
    Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.
    1. Developmental Biology

    Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation

    Helen Strutt et al.
    Casein kinase Iε phosphorylation has opposite effects on the stability of the core planar polarity proteins Strabismus and Dishevelled, leading to their sorting to opposite cell ends.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng et al.
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper et al.
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.

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