5,130 results found
    1. Developmental Biology

    Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals

    Nainoa Richardson et al.
    Sox8 can induce female-to-male sex reversal of the R-spondin1 loss-of-function mouse mutants in the absence of Sox9..
    1. Cell Biology

    A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

    Ka Man Carmen Chan et al.
    A viral fusogen drives cell-cell fusion by hijacking the actin machinery to directly couple actin assembly with a short fusogenic ectodomain.
    1. Neuroscience

    Auditory cortical alpha/beta desynchronization prioritizes the representation of memory items during a retention period

    Nathan Weisz et al.
    Top-down mediated decreases of beta activity in auditory cortex prior to a predictable distractor in an auditory working memory task is associated with increased representation of to-be-memorized information.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional properties of CALHM channels of the human placenta

    Katarzyna Drożdżyk et al.
    Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara et al.
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved and regulated mechanism drives endosomal Rab transition

    Lars Langemeyer et al.
    Reconstitution of the endosomal Rab cascade reveals that Rab5 binds and activates the Mon1-Ccz1 guanine nucleotide exchange factor, which in turn recruits Rab7 to membranes to drive fusion.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Special Issue: Call for papers in evolutionary medicine

    eLife is pleased to announce a new Special Issue, curating the very best research in this growing area.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lipid accumulation controls the balance between surface connection and scission of caveolae

    Madlen Hubert et al.
    Caveolae sense the membrane lipid composition, which influences their dynamic behavior at the cell surface.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

    Alessandro Scacchetti et al.
    Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.

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