2,141 results found
    1. Cell Biology
    2. Neuroscience

    Piezo1 links mechanical forces to red blood cell volume

    Stuart M Cahalan et al.
    In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

    Rima S Chakrabarti et al.
    Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

    Gunjan Arora et al.
    Red blood cells infected by the malaria parasite Plasmodium falciparum are destroyed by human natural killer cells in the presence of antibodies from people who have acquired clinical immunity to malaria.
    1. Microbiology and Infectious Disease

    Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

    May M Paing et al.
    Plasmodium falciparum invasion protein EBA-175, once shed from the parasite surface post invasion, facilitates RBC clustering and enhances parasite growth while simultaneously enabling parasite immune evasion of host neutralizing antibodies.
    1. Physics of Living Systems

    Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion

    Sebastian Hillringhaus et al.
    The bond-based adhesion model is a key step toward a realistic description of RBC-parasite interaction, which allows the investigation of more realistic scenarios and is relevant for other biological systems.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan et al.
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Cell Biology
    2. Human Biology and Medicine

    A critical role for mTORC1 in erythropoiesis and anemia

    Zachary A Knight et al.
    Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

    Lin Chen et al.
    The crystal structure of a PfRh family protein from a malaria parasite has been solved and shows that PfRh5-which the parasite uses to invade human red blood cells-has a novel protein fold.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

    Satish K Nandakumar et al.
    A gene-centric functional screen uncovers biological mechanisms underlying genome-wide association study signals for human red blood cell traits.

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