The person-specific adjusted HbA_1c addresses non-glycaemic variation in laboratory HbA_1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.

Heterochromatin spreading in fission yeast predominantly produces intergenerationally unstable outcomes, requiring an accessory element that represses histone turnover.

Hypobaric hypoxia exposure initiates splenic ferroptosis, reducing red pulp macrophages and exacerbating high-altitude polycythemia by impairing erythrophagocytosis and increasing red blood cell retention.

A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.

Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.

Quantitative proteomics reveals the diversity and heterogeneity of nuclear proteomes in mammalian organs and identifies the molecular features of ageing.

Germ cell ablation delays C. elegans aging, in part, because unconsumed fat triggers activation of the detoxification factor SKN-1/Nrf, which is regulated by lipid signals and maintains lipid homeostasis.

In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.

Unlike all other mammals studied to date, the age-specific risk of mortality for naked mole-rats did not increase over decades of life, identifying this species as a non-aging mammal.

Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.