3,164 results found
    1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu
    Membrane lipids are involved in the maturation and cytotoxicity of Parkinson's synphilin-1 inclusion bodies.
    1. Cell Biology

    A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

    Tamás Visnovitz, Dorina Lenzinger ... Edit I Buzas
    A novel 'torn bag mechanism' is described for the release of LC3 positive and negative small extracellular vesicles (exosomes) from amphiectosomes.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Neuroscience

    Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat

    Gyeong Hee Pyeon, Hyewon Cho ... Yong Sang Jo
    CGRP neurons act as a general alarm system, modulating various defensive behaviors based on magnitude of threat.
    1. Genetics and Genomics

    Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies

    Jorge Blanco Mendana, Margaret Donovan ... Daryl M Gohl
    A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.
    1. Cell Biology
    2. Genetics and Genomics

    The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

    Adam D Longhurst, Kyle Wang ... David P Toczyski
    An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan M Shugarts Devanapally, Aishwarya Sathya ... Antony M Jose
    Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.
    1. Developmental Biology
    2. Neuroscience

    Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo

    Taro Ichimura, Taishi Kakizuka ... Takeharu Nagai
    Volumetric trans-scale imaging with a subcellular resolution across a wide field-of-view of 1.5 × 1.0 cm2 has been realized, facilitating the analysis of cellular dynamics during embryogenesis and brain function.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Template switching during DNA replication is a frequent source of adaptive gene amplification.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete

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