Interactions of eIF4A and eIF4E with specific amino-acids in the N-terminal domain of DEAD-box helicase Ded1 enhance bulk polysome assembly and translation of reporter mRNAs with structured leaders in vivo.
Sandeep K Ravala, Sendi Rafael Adame-Garcia ... John JG Tesmer
P-Rex1 adopts an inactive, compact conformation that is stabilized by an abundant intracellular molecule and undergoes dynamic changes to extend upon encountering signaling phospholipids in membranes.
Katharina S Volz, Andrew H Jacobs ... Kristy Red-Horse
Progenitor cells for the muscle layer around the coronary arteries have been identified revealing a key step in how the embryo forms these important blood vessels.
A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.
Christine R Collins, Fiona Hackett ... Michael J Blackman
Genetic analysis identifies an enzyme of the malaria parasite that is required to seal its host red blood cell membrane upon invasion, a key requirement of this important intracellular pathogen.
Distributed cohesin rings flexibly tether the axial element structure of meiotic chromosomes to the underlying chromatin to readily accommodate ongoing transcription.
Body color change of locusts reveals a new 'palette effect' mechanism by which the red βCBP–β-carotene pigment complex acts as a switch to coordinate between black and green coloration.
