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    1. Microbiology and Infectious Disease
    2. Neuroscience

    Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide

    Yingsong Hao et al.
    C. elegans utilizes bacterially produced nitric oxide as a sensory cue to elicit avoidance of pathogenic bacteria.
    1. Plant Biology

    A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination

    Wannarat Pornsiriwong et al.
    Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.
    1. Developmental Biology

    A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

    Bin Qi et al.
    The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
    1. Structural Biology and Molecular Biophysics

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

    F Esra Demircioglu et al.
    High resolution structures of the essential human AAA+ ATPase TorsinA and its disease mutant in complex with an activator reveal details of the interaction that will guide drug design and further functional characterization.
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin et al.
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Evolutionary Biology

    The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

    Daniel B Mills et al.
    Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    How lamina-associated polypeptide 1 (LAP1) activates Torsin

    Brian A Sosa et al.
    LAP1 adopts an AAA+ like fold that, while unable to bind nucleotide, can enhance ATPase activity in the neighboring TorsinA protomer in an unusual heterohexameric ring, via an arginine finger.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reactive oxygen species oxidize STING and suppress interferon production

    Lili Tao et al.
    Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.