320 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

    Aurore L'honoré et al.
    Modulation of muscle stem cell redox state in culture both improves their amplification while maintaining a similar grafting potential as freshly isolated stem cells.
    1. Ecology
    2. Microbiology and Infectious Disease

    Light-dependent single-cell heterogeneity in the chloroplast redox state regulates cell fate in a marine diatom

    Avia Mizrachi et al.
    Single-cell analysis of the chloroplast redox response to high light and oxidative stress revealed light-dependent heterogeneity, and was linked to cell fate determination within isogenic diatom populations.
    1. Microbiology and Infectious Disease

    Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

    Aspen T Reese et al.
    Disturbing the microbiota with antibiotics alters gut redox state via changes in electron acceptor availability, setting the stage for post-antibiotic succession.
    1. Cell Biology

    Mitochondrial Homeostasis: Auto-regulation in the powerhouse

    Helena M Viola, Livia C Hool
    Mitochondrial flashes have a central role in ensuring that ATP levels remain constant in heart cells.
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    1. Developmental Biology

    A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

    Bin Qi et al.
    The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Plant Biology

    A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination

    Wannarat Pornsiriwong et al.
    Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.
    1. Evolutionary Biology

    The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

    Daniel B Mills et al.
    Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.
    1. Cancer Biology

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

    Elsa B Krall et al.
    Loss of KEAP1 modulates sensitivity to targeted therapies in lung cancer.

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