117 results found
    1. Structural Biology and Molecular Biophysics

    Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

    Piotr Kolata, Rouslan G Efremov
    The dynamic structure of respiratory complex I from mesophilic bacterium is revealed and demonstrates existence of uncoupled conformations in the bacterial complex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
    1. Biochemistry and Chemical Biology

    Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

    Valentina Peleh et al.
    The import of proteins into the intermembrane space of mitochondria is driven by binding to the trans-site receptor Mia40 and not by the oxidation of cysteine residues.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of respiratory complex I at work

    Kristian Parey et al.
    The site of ubiquinone binding observed in the cryo-EM structure of respiratory complex I during turnover supports a two-state stabilization change mechanism.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

    Arne Sahm et al.
    The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado et al.
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

    Jie Wang et al.
    Direct modification by endogenous peroxide of a conserved cysteine in the molecular chaperone BiP decouples its ATPase and peptide-binding activities, allowing for enhanced polypeptide holdase activity during oxidative stress.
    1. Biochemistry and Chemical Biology

    Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

    Raphaël Méheust et al.
    Bioinformatic and biochemical studies provide evidence that covalently bound flavins are common and participate in wide-ranging extracytosolic redox activities throughout bacterial life.
    1. Neuroscience

    Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

    Alan Jung Park et al.
    Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.

Refine your results by:

Type
Research categories