A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.

Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.

Using multiple analysts to independently analyze the same dataset has the potential to explore and strengthen the robustness of results and conclusions in basic and applied research.

RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.

A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.

Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.

A novel mathematical strategy for the integrated analysis of adult body structures quantifies the degree and nature of developmental robustness and its evolutionary implications.

The cerebellum encodes self-generated head rotations in a head posture-dependent manner, providing in particular a representation of how the head rotates about axes referenced relative to gravity.

A new autoencoder-based genotype imputation method shows superior accuracy across human genomes of diverse ancestry and across the allele-frequency spectrum, while delivering significantly faster inference run times relative to standard imputation tools.

Three new protein markers of testosterone action identified by us, may prove to be valuable as clinical tools in identifying men with testosterone deficiency and in monitoring androgen replacement therapy.