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    1. Neuroscience

    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

    Judit García-González et al.
    Zebrafish studies are able to predict loci and biological pathways affecting human behaviour, paving the way to better understanding of the biological underpinnings of psychiatric disease.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

    Agata Wesolowska-Andersen et al.
    Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic et al.
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history and genomics of European blackcap migration

    Kira Delmore et al.
    Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
    1. Plant Biology

    The Arabidopsis thaliana mobilome and its impact at the species level

    Leandro Quadrana et al.
    Population genomics in Arabidopsis thaliana uncovers an extensive repertoire of active transposable element families at the species level and reveals their importance as a source of rare alleles with large effects.
    1. Genetics and Genomics

    Population-scale proteome variation in human induced pluripotent stem cells

    Bogdan Andrei Mirauta et al.
    Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Controlling gene activation by enhancers through a drug-inducible topological insulator

    Taro Tsujimura et al.
    A novel synthetic DNA cassette of CTCF-binding sites combined with the drug-controllable induction system of heterochromatin enabled switchable blocking of chromatin conformation and gene-enhancer interaction.
    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer et al.
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Neuroscience

    Common cell type nomenclature for the mammalian brain

    Jeremy A Miller et al.
    A new nomenclature convention for mammalian cell types utilizing shared taxonomies and quantitative cell features is applied to high-quality, open data from the mouse and human brain.
    1. Genetics and Genomics

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo et al.
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.