2,671 results found
    1. Neuroscience

    Selective rab11 transport and the intrinsic regenerative ability of CNS axons

    Hiroaki Koseki et al.
    Mature axons lose the ability to regenerate because key growth molecules are excluded through changes in vesicle transport, and restoring transport can restore regeneration.
    1. Neuroscience

    CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

    Lizhen Chen et al.
    Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
    1. Stem Cells and Regenerative Medicine

    Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling

    Michael A Gaviño et al.
    Flatworm regeneration of lost tissue relies on a mechanism distinct from that used for routine tissue turnover.
    1. Cell Biology
    2. Developmental Biology

    Macrophages are necessary for epimorphic regeneration in African spiny mice

    Jennifer Simkin et al.
    Inflammatory cells differentially regulate a scarring versus a regenerating response to injury in mammals.
    1. Stem Cells and Regenerative Medicine

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Neuroscience

    Inhibiting poly(ADP-ribosylation) improves axon regeneration

    Alexandra B Byrne et al.
    In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
    1. Neuroscience

    GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

    Xinzheng Guo et al.
    The AKT-GSK3β-eIF2Bε signaling module plays a key role in promoting axon regeneration in the adult mammalian central nervous system.
    1. Neuroscience

    mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

    Linqing Miao et al.
    The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith et al.
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler et al.
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.

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