4,805 results found
  1. Philosophy of Biology: Understanding regeneration at different scales

    Kate MacCord, Jane Maienschein
    To understand how regeneration works across the different scales of living systems, we first need to identify the essential components underlying this process.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila

    Robin E Harris et al.
    The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Distinct progenitor populations mediate regeneration in the zebrafish lateral line

    Eric D Thomas, David W Raible
    The zebrafish lateral line utilizes multiple, genetically distinct, independently regulated progenitors to generate new hair cells during homeostasis and regeneration, and to maintain progenitor pools.
    1. Cell Biology
    2. Developmental Biology

    Macrophages are necessary for epimorphic regeneration in African spiny mice

    Jennifer Simkin et al.
    Inflammatory cells differentially regulate a scarring versus a regenerating response to injury in mammals.
    1. Neuroscience

    CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

    Lizhen Chen et al.
    Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
    1. Stem Cells and Regenerative Medicine

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Neuroscience

    Selective rab11 transport and the intrinsic regenerative ability of CNS axons

    Hiroaki Koseki et al.
    Mature axons lose the ability to regenerate because key growth molecules are excluded through changes in vesicle transport, and restoring transport can restore regeneration.
    1. Stem Cells and Regenerative Medicine

    Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling

    Michael A Gaviño et al.
    Flatworm regeneration of lost tissue relies on a mechanism distinct from that used for routine tissue turnover.

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