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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+ epicardial cells

    Na Li, Stephanie Rignault-Clerc ... Nathalie Rosenblatt-Velin
    Brain natriuretic peptide supplementation can increase cardiac neovascularization in infarcted hearts by stimulating endogenous endothelial cell proliferation and proliferation of precursor cells, which will differentiate into endothelial cells.
    1. Computational and Systems Biology
    2. Plant Biology

    A coupled mechano-biochemical model for cell polarity guided anisotropic root growth

    Marco Marconi, Marcal Gallemi ... Krzysztof Wabnik
    The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.
    1. Biochemistry and Chemical Biology

    Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

    Mengyang Fan, Wenchao Lu ... Nathanael S Gray
    Discovery of potent covalent TEAD palmitoylation inhibitors that represents important tools to investigate the Hippo pathway.
    1. Medicine
    2. Neuroscience

    The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

    Xueyong Wang, Murad Nawaz ... Mark M Rich
    Detailed studies of excitation contraction coupling allowed determination of quantitative relationships between resting potential, generation of action potentials, conduction of action potentials, and generation of Ca2+ transients in individual mouse skeletal muscle fibers.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the disaggregase activity and regulation of Hsp104

    Alexander Heuck, Sonja Schitter-Sollner ... Tim Clausen
    Protein disaggregases employ two mechanically-linked ATPase rings that are under steric control by a wrapped-around coiled-coil belt.
    1. Developmental Biology
    2. Evolutionary Biology

    Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

    Jonathan E Phillips, Maribel Santos ... Duojia Pan
    Genome editing in a close unicellular relative of animals suggests a premetazoan function of the Hippo pathway effector YAP/TAZ/Yorkie in the regulation of cytoskeletal dynamics and multicellular morphogenesis but not proliferation.
    1. Cell Biology
    2. Developmental Biology

    Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation

    Mengmeng Zhou, Yuhong Han, Jin Jiang
    Phosphorylation of the pseudokinase Ulk4 by Stk36 promotes primary ciliary tip localization of both proteins to facilitate the phosphorylation and activation of Gli in response to Sonic hedgehog.
    1. Cancer Biology

    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

    Guillaume Jacquemin, Annabelle Wurmser ... Silvia Fre
    Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
    1. Medicine

    High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

    Ok-Hee Kim, Carmen J Booth ... Byung-Chul Oh
    A high-phytate-low Ca2+ diet causes crystal nephropathies, renal phosphate wasting, and bone disease in rats, whereas high Ca2+ intake ameliorates the detrimental effects of a high-phytate diet.
    1. Developmental Biology
    2. Neuroscience

    Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells

    Tanya L Brown, Emma C Horton ... Jeffrey P Rasmussen
    Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.