Na Li, Stephanie Rignault-Clerc ... Nathalie Rosenblatt-Velin
Brain natriuretic peptide supplementation can increase cardiac neovascularization in infarcted hearts by stimulating endogenous endothelial cell proliferation and proliferation of precursor cells, which will differentiate into endothelial cells.
Marco Marconi, Marcal Gallemi ... Krzysztof Wabnik
The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.
Detailed studies of excitation contraction coupling allowed determination of quantitative relationships between resting potential, generation of action potentials, conduction of action potentials, and generation of Ca2+ transients in individual mouse skeletal muscle fibers.
Jonathan E Phillips, Maribel Santos ... Duojia Pan
Genome editing in a close unicellular relative of animals suggests a premetazoan function of the Hippo pathway effector YAP/TAZ/Yorkie in the regulation of cytoskeletal dynamics and multicellular morphogenesis but not proliferation.
Phosphorylation of the pseudokinase Ulk4 by Stk36 promotes primary ciliary tip localization of both proteins to facilitate the phosphorylation and activation of Gli in response to Sonic hedgehog.
Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
A high-phytate-low Ca2+ diet causes crystal nephropathies, renal phosphate wasting, and bone disease in rats, whereas high Ca2+ intake ameliorates the detrimental effects of a high-phytate diet.
Tanya L Brown, Emma C Horton ... Jeffrey P Rasmussen
Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.