The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
A discrete group of interconnected neurons are shown to drive aggressive social interactions in Drosophila females and genetic tools to manipulate these neuronal cell types are provided.
A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
Representations in the subcortical sensory pathway do not only adapt to stimulus properties but also rely on the observer’s subjective model of the world.
Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.
Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.
Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.
Representation of goals in the forms previously reported in the PFC is not required for performance of a novel spatial working memory task where goal information must be used flexibly.
