Skip to Content
eLife home page
Submit my research
(via ORCID - An ORCID is a persistent digital identifier for researchers)
Browse the search results
Page 3 of 328
Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions
José Antonio Escudero et al.
The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
Helen Wong et al.
Murine behavioral testing and biochemical experiments reveal AKT isoform- and sex-dependent mechanisms regulating affective behavior, memory formation, and extinction.
Cell types and neuronal circuitry underlying female aggression in
Catherine E Schretter et al.
A discrete group of interconnected neurons are shown to drive aggressive social interactions in
females and genetic tools to manipulate these neuronal cell types are provided.
The neural basis for a persistent internal state in
David Deutsch et al.
A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
Abstract rules drive adaptation in the subcortical sensory pathway
Alejandro Tabas et al.
Representations in the subcortical sensory pathway do not only adapt to stimulus properties but also rely on the observer’s subjective model of the world.
Constitutive activation of cellular immunity underlies the evolution of resistance to infection in
Alexandre B Leitão et al.
Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.
Genetics and Genomics
Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest
Noa Aharon-Hefetz et al.
Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations
Jone Paesmans et al.
Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
Physics of Living Systems
Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle
Yong Li et al.
Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.
Canonical goal-selective representations are absent from prefrontal cortex in a spatial working memory task requiring behavioral flexibility
Claudia Böhm, Albert K Lee
Representation of goals in the forms previously reported in the PFC is not required for performance of a novel spatial working memory task where goal information must be used flexibly.
Be the first to read new articles from eLife
Sign up for alerts
Please leave this field empty
Back to top