The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.

Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.

The examination of the ultra-structure and in vivo dynamics of endocytosis in plants reveal plants unique actin-independent, clathrin-mediated endocytosis mechanisms to overcome their unique physiological properties.

Memory guides attention by enabling preparation for upcoming states in the hippocampus and medial prefrontal cortex.

A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.

Genetic and electrophysiological analyses reveal that the mechanisms orchestrating the induction and expression of homeostatic plasticity are compartmentalized and operate with exquisite specificity on both sides of the synapse.

Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.

Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.

Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.