3,024 results found
    1. Cell Biology

    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

    Andrew Ying Hui Ng et al.
    Rgs12 protein is a novel regulator of the Nrf2 protein by facilitating the proteasomal degradation of the transcription factor during osteoclast differentiation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

    Weiwei Wang et al.
    The G protein subunits Gβγ and the signaling lipid PIP2 are simultaneously needed to activate the potassium ion channel GIRK2 to control the voltage across a lipid bilayer, while sodium ions modulate these molecules' effects.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

    Dipak N Patil et al.
    Atomic details on structural organization and conformational dynamics of the key regulator of neuronal signaling shed light on its allosteric regulation and role in regulating cellular pathways.
    1. Cell Biology
    2. Plant Biology

    Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor

    Xiangxiu Liang et al.
    Heterotrimeric G proteins are coupled to and regulate plant receptor signaling, which allows optimum immune activation and enhances the production of reactive oxygen species.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: Solving a specificity mystery

    Sanduo Zheng, Andrew C Kruse
    Differences in the kinetics of G protein activation can explain why only some receptors can activate potassium ion channels called GIRKs.
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    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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    1. Cell Biology
    2. Neuroscience

    Hypoxia: Adapt or avoid

    Ganesh K Kumar
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    1. Cancer Biology

    Cancer Risk: Why do women with melanoma do better than men?

    Keiran SM Smalley
    Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.
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    1. Ecology

    Mass Spawning: Sex under the moon

    Didier Zoccola, Sylvie Tambutté
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