2,570 results found
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic and epigenetic variation in the lineage specification of regulatory T cells

    Aaron Arvey et al.
    There is limited epigenetic conservation of lineage-specific DNA elements in Treg cells, and genetic variation in Treg cell specific enhancers is associated with autoimmune disease.
    1. Cell Biology
    2. Immunology and Inflammation

    Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells

    Nimi Marcel, Apurva Sarin
    Notch1 activates autophagy to regulate the survival of T-regulatory cells from mice.
    1. Immunology and Inflammation

    Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

    Antonio P Baptista et al.
    MHC class II-mediated self-antigen presentation by lymph node stromal cells controls regulatory T cell homeostasis, thus safeguarding immune tolerance.
    1. Immunology and Inflammation

    T cell-intrinsic role of IL-6 signaling in primary and memory responses

    Simone A Nish et al.
    IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.
    1. Immunology and Inflammation
    2. Cell Biology

    Calcium-mediated shaping of naive CD4 T-cell phenotype and function

    Vincent Guichard et al.
    Calcium-calcineurin signaling cascade drives the acquisition of both the phenotype of the most self-reactive naive CD4 T cells and their enhanced cell-intrinsic ability to commit into induced regulatory T cells upon activation.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

    Bernard Khor et al.
    A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.
    1. Cell Biology
    2. Immunology and Inflammation

    Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

    Alejandro Villarino et al.
    Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.
    1. Immunology and Inflammation

    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

    Xiaomei Yuan et al.
    Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

    Haichuan Zhu et al.
    The identification of key determinants of LSC “stemness” and LSC differentiation that is reversible through an epigenetic mechanism may have considerable implications in understanding leukemia and designing effective therapies.
    1. Immunology and Inflammation

    Autophagy is a critical regulator of memory CD8+ T cell formation

    Daniel J Puleston et al.
    Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.

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