1,942 results found
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra et al.
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Cancer Biology

    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

    CheukMan C Au et al.
    3D culture of breast cancer in biologically relevant ECM potentiates the growth-inhibitory effects of unacylated ghrelin and AZP-531, and clinical response may be predictable based on a MAPK gene signature.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Dynamic metastable long-living droplets formed by sticker-spacer proteins

    Srivastav Ranganathan, Eugene I Shakhnovich
    Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.
    1. Cell Biology
    2. Immunology and Inflammation

    CD56 regulates human NK cell cytotoxicity through Pyk2

    Justin T Gunesch et al.
    CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez et al.
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
    1. Cell Biology

    Assigning mitochondrial localization of dual localized proteins using a yeast Bi-Genomic Mitochondrial-Split-GFP

    Gaétan Bader et al.
    The Bi-Genomic Mitochondrial-Split-GFP, where both fragments of the Split-GFP are expressed by separated translation machineries, shuts off cytosolic fluorescence of dual-localized proteins, allowing visualization of their mitochondrial echoforms.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Immunology and Inflammation

    CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

    Joan Manils et al.
    Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira et al.
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Biochemistry and Chemical Biology

    Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

    Iti Kapoor et al.
    Biochemical and structural biological analyses show how bacteria can recognize hormones that control the production of important secondary metabolites such as antiparasitics and antibiotics.

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