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    1. Neuroscience

    Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence

    Avital Hahamy, Stamatios N Sotiropoulos ... Tamar R Makin
    Building on previous work (Makin et al., 2013), we show that the brains of individuals born without a hand adaptively change to compensate for their disability.
    1. Neuroscience

    Unraveling the impact of congenital deafness on individual brain organization

    Lénia Amaral, Xiaosha Wang ... Ella Striem-Amit
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis

    Sergey D Stavisky, Francis R Willett ... Jaimie M Henderson
    Neurons in human dorsal motor cortex, an area involved in controlling arm and hand movements, are also active – and show similar ensemble dynamics – during speaking.
    1. Neuroscience

    Intramuscular Neurotrophin-3 normalizes low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats

    Claudia Kathe, Thomas Haynes Hutson ... Lawrence David Falcon Moon
    Delayed intramuscular gene therapy with neurotrophin-3 after corticospinal tract injury reduces spasticity and improves locomotion by treating underlying causes of spasticity.
    1. Neuroscience

    Neural activity related to volitional regulation of cortical excitability

    Kathy Ruddy, Joshua Balsters ... Nicole Wenderoth
    Changing brain state using feedback from transcranial magnetic stimulation, by training participants to increase or decrease how excitable their motor pathways are.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa, Annett Neuner ... Yoshinobu Kaneko
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Neuroscience

    Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

    Nicole Rosskothen-Kuhl, Alexa N Buck ... Jan WH Schnupp
    Early deaf human CI users are often insensitive to sub-millisecond interaural time differences (ITDs); however, with synchronized CIs, early deafened rats learned to lateralize small ITDs near 50 µs.
    1. Neuroscience

    Deprivation-related and use-dependent plasticity go hand in hand

    Tamar R Makin, Alona O Cramer ... Heidi Johansen-Berg
    In individuals with a missing hand, the area of the brain that would otherwise control that hand is recruited by either the remaining hand or the residual limb, depending on the usage preference of the individual.
    1. Medicine

    Risk of motor vehicle collisions after methadone use

    Ya-Hui Yang, Pei-Shan Ho ... Hung-Yi Chuang
    Methadone maintenance treatment (MMT) can alleviate opioid dependence, however, drivers receiving MMT were at high risk of motor vehicle collisions in the present study, particularly the first 90 days of MMT.
    1. Epidemiology and Global Health
    2. Medicine

    Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial

    Thomas Sonnweber, Piotr Tymoszuk ... Judith Löffler-Ragg
    Protracted systemic and microvascular inflammation, as well as high anti-SARS-CoV-2 antibody levels, is associated with a high risk of persistent structural and functional lung deficits 6 months after COVID-19.