176 results found
  1. Episode 45: February 2018

    In this episode, we hear about disease control in insects, placental development, post-traumatic stress disorder, the mission to create a human cell atlas and how crickets amplify their song.
    1. Immunology and Inflammation

    Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection

    Ana-Carolina Oliveira et al.
    Development of a robust Th1 response to infection against an intracellular parasite requires T-cell intrinsic MyD88 signaling, mostly through the upstream IL-18 receptor, for the induction of genes involved in proliferation, cytokine production and migration.
    1. Cell Biology
    2. Genetics and Genomics

    Rapid re-identification of human samples using portable DNA sequencing

    Sophie Zaaijer et al.
    DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.
    1. Neuroscience

    Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

    Hala Harony-Nicolas et al.
    The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional deficits.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Ioanna Oikonomidi et al.
    Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
    1. Cell Biology

    Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes

    Patrina A Pellett et al.
    Evidence that certain proteins can be transported between Golgi via structures that resemble COPI vesicles suggests that these vesicles could also be involved in the transport of proteins from the cis to the trans face of the Golgi.
    1. Neuroscience

    Conditioning sharpens the spatial representation of rewarded stimuli in mouse primary visual cortex

    Pieter M Goltstein et al.
    Stimulus-reward learning sharpens the local representation of the visual space while leaving the overall retinotopic map intact.
    1. Neuroscience

    Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task

    Brian F Sadacca et al.
    Neural activity in the orbitofrontal cortex (OFC) represents incidental stimulus-stimulus associations, providing additional evidence for OFC having a role in cognition beyond functions centered on processing value or biological significance.
    1. Cell Biology

    Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

    Yidi Sun et al.
    Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
    1. Neuroscience

    Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory in Aplysia

    Kaycey Pearce et al.
    Behavioral and synaptic investigations of long-term memory in Aplysia reveal differing roles for DNA methylation, protein synthesis during training and protein synthesis shortly after training with respect to memory consolidation and maintenance.

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