26 results found
    1. Cell Biology
    2. Developmental Biology

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Cell Biology

    Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

    Grant A King et al.
    A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.
    1. Cell Biology

    Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans

    Nikolay Burnaevskiy et al.
    Morphological and functional rejuvenation upon exit from adult reproductive diapause in C. elegans is independent of germline signaling, but instead involves somatic nucleolar activation and expansion of the RNA pool.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

    Lauren N Booth et al.
    Nematode hermaphroditism has co-evolved with a self-sperm sensing mechanism that protects hermaphrodites from the detrimental effects of mating with males.
    1. Developmental Biology
    2. Human Biology and Medicine

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe et al.
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt et al.
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Protein biogenesis machinery is a driver of replicative aging in yeast

    Georges E Janssens et al.
    A comprehensive mapping of the proteome and transcriptome during the complete replicative lifespan of budding yeast predicted an increased abundance of the protein biogenesis machinery is most causal for aging.
    1. Developmental Biology

    Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut

    Erez Cohen et al.
    Ploidy-increasing endocycles may represent a tradeoff between loss of regenerative capacity and preservation of tissue architecture.
    1. Cell Biology

    The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance

    Francisco J Piña, Maho Niwa
    Endoplasmic reticulum (ER) inheritance regulation during ER stress controls the transmission of misfolded ER proteins from mother to daughter cell in budding yeast.

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