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Early oocyte development takes place in germline cysts and is strikingly conserved from Drosophila to mouse, reflecting common mechanisms that may help reverse aging and specify oocyte and early embryo polarity.

Stimulus representation in primary visual cortex rebounds to its original state following therapeutic sensory deprivation in adults.

Regulation of Cav2.3 Ca²⁺ channels by membrane-bound β2 subunit splice variants permits long-lasting channel activity even during prolonged and continuous activity in dopamine neurons, with implications for Parkinson's disease pathophysiology.

Spermidine-mediated superoxide generation affects iron homeostasis in Escherichia coli.

Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.

Cell encapsulation-based transcriptional profiling using myogenic progenitors reveals that long-range factors in the aged systemic environment induce a wide range of signaling pathways in a niche-independent manner.

The cryo-EM structures of actomyosin-V, including a novel strongly bound post-rigor transition state, reveal a pronounced structural heterogeneity of myosin-V and the specific selection of the closed D-loop conformation of F-actin.

Lung stem cell niche aging is associated with altered bioenergetics, metabolic dysfunction, and senescence of mesenchymal stromal cells that restricts 3D organoid, or alveolosphere formation, potentially accounting for reduced regenerative capacity with aging.

Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.