2,200 results found
    1. Medicine

    Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

    Danae E Zamboulis et al.
    Phase-specific mechanical and proteomic analyses reveal how tendon responds to its mechanical environment during postnatal development to meet functional requirements.
    1. Immunology and Inflammation

    Critical role of WNK1 in MYC-dependent early mouse thymocyte development

    Robert Köchl et al.
    Development of mouse thymocytes through the pre-TCR checkpoint requires WNK1 kinase signalling via the OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter leading to MYC-dependent cell proliferation.
    1. Genetics and Genomics
    2. Medicine

    Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

    Pedrum Mohammadi-Shemirani et al.
    Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
    1. Neuroscience

    Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

    Bob Bramson et al.
    Non-invasive manipulation of endogenously coupled neural rhythms enhances human control of social-emotional actions.
    1. Biochemistry and Chemical Biology

    Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

    Marija Liutkute et al.
    HemK NTD cotranslational folding starts within the ribosome exit tunnel upon N-terminal helix synthesis and proceeds sequentially through a series of intermediates becoming less dynamic as the nascent chain grows.
    1. Neuroscience

    Distinct hierarchical alterations of intrinsic neural timescales account for different manifestations of psychosis

    Kenneth Wengler et al.
    fMRI evidence for distinct hierarchical alterations in intrinsic neural timescales for different positive symptoms of schizophrenia support hierarchical perceptual-inference models of psychosis and suggest local increases in excitation-inhibition ratio.
    1. Neuroscience

    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

    Daniel J Millman et al.
    Measurements of visual response to motion of different contrasts along with network modeling reveals a microcircuit in superficial layers of cortex that regulates the gain regime.
    1. Medicine
    2. Neuroscience

    APOE2 is associated with longevity independent of Alzheimer’s disease

    Mitsuru Shinohara et al.
    Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei et al.
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Genetics and Genomics
    2. Neuroscience

    Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

    Marina Kovalenko et al.
    Genetic knockout of Hdac2 modifies molecular and cellular phenotypes in Huntington’s disease mice and has a prominent transcriptional regulatory role in adult medium spiny neurons.

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