Browse the search results

Page 2 of 113
    1. Neuroscience

    Multi-contrast anatomical subcortical structures parcellation

    Pierre-Louis Bazin et al.
    An open-source software tool enables the anatomical parcellation of an unprecedented number of subcortical structures in magnetic resonance images of the human brain, automatically and in individual subjects.
    1. Neuroscience

    Dendritic coincidence detection in Purkinje neurons of awake mice

    Christopher J Roome, Bernd Kuhn
    Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.
    1. Neuroscience

    Topographic gradients of intrinsic dynamics across neocortex

    Golia Shafiei et al.
    Intrinsic dynamics are shaped by the intersection of molecular, microstructural, connectomic, and activation gradients.
    1. Ecology
    2. Evolutionary Biology

    Does diversity beget diversity in microbiomes?

    Naïma Madi et al.
    Microbiomediversity favors further diversity in a positive feedback that is strongest in lower-diversity biomes but which plateaus as niches are increasingly filled in higher-diversity biomes.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
    1. Neuroscience

    Impaired adaptation of learning to contingency volatility in internalizing psychopathology

    Christopher Gagne et al.
    Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
    1. Cell Biology
    2. Medicine

    MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

    Shilpak Bele et al.
    Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
    1. Neuroscience

    Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

    Minhui Ouyang et al.
    Diffusion-MRI-based cerebral cortical microstructure encoding regionally differential dendritic arborization and synaptic formation at birth robustly predicts future 2-year-old cognitive and language outcomes with regionally heterogeneous contribution that exhibits functional selectivity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris et al.
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Computational and Systems Biology

    A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

    Dennis Wang et al.
    Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.