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    1. Neuroscience

    The influence of evidence volatility on choice, reaction time and confidence in a perceptual decision

    Ariel Zylberberg et al.
    A single framework of bounded evidence accumulation resolves the seemingly paradoxical effects of noise on accuracy, reaction time and confidence.
    1. Neuroscience

    Natural ITD statistics predict human auditory spatial perception

    Rodrigo Pavão et al.
    Human brain has incorporated natural statistics of spatial cues to the neural code supporting perception of sound location.
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson et al.
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Cell Biology

    An adaptation of astronomical image processing enables characterization and functional 3D mapping of individual sites of excitation-contraction coupling in rat cardiac muscle

    Qinghai Tian et al.
    The fusion of astronomy and cellular cardiology reveals the 3D arrangement and the firing reliability of active excitation-contraction coupling sites in beating cardiac myocytes.
    1. Neuroscience

    A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task

    Frederick Verbruggen et al.
    Clear guidelines and open-source software resources are provided for the stop-signal task, in order to streamline the use of this important tool, and to thereby increase its validity and reliability.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Anti-Cancer Drugs: The mitochondrial paradox

    Sophie L Penman et al.
    A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

    Zoe A Stephenson et al.
    A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.
  1. Point of View: Four erroneous beliefs thwarting more trustworthy research

    Mark Yarborough et al.
    Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.
  2. Philosophy of Biology: Philosophical bias is the one bias that science cannot avoid

    Fredrik Andersen et al.
    Scientists should be aware of the non-empirical assumptions that influence all kinds of research.