6,295 results found
    1. Neuroscience

    Differential processing of decision information in subregions of rodent medial prefrontal cortex

    Geoffrey W Diehl, A David Redish
    A novel method of recording neural activity from the rodent medial prefrontal cortex reveals that the medial prefrontal cortex is composed of functionally distinct subregions that process economic decision information differentially along a dorso-ventral gradient.
    1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich
    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
    1. Cell Biology
    2. Genetics and Genomics

    Rapid re-identification of human samples using portable DNA sequencing

    Sophie Zaaijer, Assaf Gordon ... Yaniv Erlich
    DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji, Dominic T Love ... Lena Claesson-Welsh
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Cell Biology

    BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

    Laura Bel Borja, Flavie Soubigou ... Federico Pelisch
    BUB-1 recruits PP2A/B56 to regulate chromosome congression in meiosis I.
    1. Computational and Systems Biology
    2. Neuroscience

    Dissecting muscle synergies in the task space

    David O'Reilly, Ioannis Delis
    A novel network information framework quantifies muscle interactions, characterises their task-relevance, and identifies networks of muscles with similar and complementary functional roles.
    1. Cancer Biology

    STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

    Stephen D'Amico, Varvara Kirillov ... Nancy C Reich
    Results show that STAT3 and KRAS jointly regulate oncogenic dependency of mutant KRAS cancer cells.
    1. Neuroscience

    Dorsal periaqueductal gray ensembles represent approach and avoidance states

    Fernando MCV Reis, Johannes Y Lee ... Avishek Adhikari
    Distinct dorsal periaqueductal gray ensembles encode threat approach and avoidance behavioral states.
    1. Structural Biology and Molecular Biophysics

    Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

    Andrew John Knappenberger, Caroline Wetherington Reiss, Scott A Strobel
    RNA aptamers that are closely related and share a common scaffold can readily adapt to recognize new ligands through changes in just a few nucleotides.

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