3,602 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Basis of specificity for a conserved and promiscuous chromatin remodeling protein

    Drake A Donovan et al.
    The identification of a novel mechanism of chromatin remodeling, including a conserved remodeler domain and regulatory epitopes, provides targets for the design of therapeutics to modulate transcriptional regulation in cells.
    1. Computational and Systems Biology
    2. Medicine

    Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

    Savannah F Bifulco et al.
    In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.
    1. Biochemistry and Chemical Biology

    Dynamic regulation of transcription factors by nucleosome remodeling

    Ming Li et al.
    Single molecule DNA unzipping reveals a novel model for the regulation of transcription factors and nucleosome positioning via nucleosome remodeling in yeast.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling

    Sharon E Torigoe et al.
    The Chd1 motor protein performs two functionally distinct ATP-dependent activities, nucleosome assembly and chromatin remodeling, to generate periodic arrays of nucleosomes.
    1. Epidemiology and Global Health
    2. Medicine

    Mathematical modeling of the West Africa Ebola epidemic

    Jean-Paul Chretien et al.
    A review of mathematical models applied to the West Africa Ebola epidemic suggests ways to improve the use of mathematical modeling in responding to public health emergencies.
    1. Cell Biology

    Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

    Nicolas Baeyens et al.
    Flow-dependent remodeling of blood vessels is critical for normal physiology and for recovery from arterial blockage in disease; understanding its cellular mechanisms may lead to the development of treatments for patients that are deficient in this process following myocardial infarction or other vascular diseases.
    1. Computational and Systems Biology
    2. Ecology

    Lotka-Volterra pairwise modeling fails to capture diverse pairwise microbial interactions

    Babak Momeni et al.
    With mathematical modeling being an important source of insight for microbial communities, we may need to move beyond commonly-used pairwise models that do not capture microbial interactions.
    1. Biochemistry and Chemical Biology

    Stepwise nucleosome translocation by RSC remodeling complexes

    Bryan T Harada et al.
    Single molecule FRET reveals that the SWI/SNF-family remodeling enzyme RSC translocates nucleosomes along the DNA in steps of ~1-2 base pairs in size.
    1. Developmental Biology

    Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

    Kenji Kamimoto et al.
    Clonal tracing in vivo and quantitative modeling in silico reveal a unique mode of tissue growth and structural remodeling of the biliary system, providing an insight into the cellular basis for robust liver regeneration.
    1. Chromosomes and Gene Expression

    Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

    Davide M Coda et al.
    NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.

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