3,739 results found
    1. Neuroscience

    Voluntary and involuntary contributions to perceptually guided saccadic choices resolved with millisecond precision

    Emilio Salinas et al.
    Looking away from a salient visual stimulus pits the reflexive urge to look toward it against the voluntary intention not to, and this conflict is resolved within tens of milliseconds.
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd et al.
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann et al.
    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.
    1. Cell Biology

    In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

    Alison K Gillingham et al.
    Relocation of Rab, Ras and Rho family GTPases to the surface of mitochondria enables efficient identification of their effectors, exchange factors and GAPs by proximity biotinylation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

    Dylan Kotliar et al.
    A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.
    1. Neuroscience

    Network-wide abnormalities explain memory variability in hippocampal amnesia

    Georgios PD Argyropoulos et al.
    Hippocampal damage is associated with changes across the extended hippocampal system, and these may explain variability in memory between patients presenting with hippocampal amnesia.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel et al.
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Developmental Biology
    2. Neuroscience

    Anterior CNS expansion driven by brain transcription factors

    Jesús Rodriguez Curt et al.
    The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
    1. Developmental Biology

    Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

    Jorge López-Tello et al.
    Fetus and trophoblast interplay to regulate fetal nutrient supply and, ultimately, affect healthy growth.

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