3,843 results found
    1. Medicine

    High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

    Ok-Hee Kim et al.
    A high-phytate-low Ca2+ diet causes crystal nephropathies, renal phosphate wasting, and bone disease in rats, whereas high Ca2+ intake ameliorates the detrimental effects of a high-phytate diet.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour et al.
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Cancer Biology

    Science Forum: An open investigation of the reproducibility of cancer biology research

    Timothy M Errington et al.
    The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.
    1. Neuroscience
    2. Medicine

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis et al.
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Microbiology and Infectious Disease

    Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators

    Jutta Nesper et al.
    Precise control of the bacterial flagellar motor determines bacterial cell dispersal and bacteria-surface interactions.
    1. Evolutionary Biology
    2. Plant Biology

    Independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

    Tobias Züst et al.
    A gain-of-function in a new chemical defense resulted in no trade-offs and and independent evolution between novel and ancestral defenses, suggesting low redundancy among different defensive chemicals.
    1. Cell Biology

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola et al.
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Neuroscience

    The manifold structure of limb coordination in walking Drosophila

    Brian D DeAngelis et al.
    During walking and turning, the fruit fly Drosophila uses variable limb coordination patterns, which exist on a low-dimensional, continuous manifold.

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