7,144 results found
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

    Natasa Savic et al.
    Linking the DNA repair template to the Cas9 ribonucleoprotein complex enhances homology-directed repair of the induced DNA double strand break.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

    Yoshitaka Kawasoe et al.
    Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.
    1. Chromosomes and Gene Expression

    Enhancement of homology-directed repair with chromatin donor templates in cells

    Grisel Cruz-Becerra, James T Kadonaga
    Precise genome editing by homology-directed repair occurs more efficiently with a chromatin donor template than with a naked DNA donor template.
    1. Neuroscience

    LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

    Jing-Ping Lin et al.
    In oligodendrocyte progenitor cells, lipid metabolism and peroxisome biogenesis are regulated by the low-density lipoprotein related-receptor-1, and if disrupted, impair proper white matter development and adult repair.
    1. Cell Biology

    Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

    Songli Zhu et al.
    Kinesin Kif2C is recruited to DNA damage sites, modulates the mobility and dynamics of DNA damage foci, and promotes DNA double strand break repair.
    1. Chromosomes and Gene Expression

    RNase H enables efficient repair of R-loop induced DNA damage

    Jeremy D Amon, Douglas Koshland
    In addition to causing DNA damage, R-loops cause genomic instability by interfering with DNA repair.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne et al.
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

    Jaigeeth Deveryshetty et al.
    Biochemical studies revealed novel property of human tumor suppressor PALB2, which significantly contribute into DNA repair in cells and can be targeted for the development of novel anticancer treatment.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu et al.
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.
    1. Developmental Biology

    Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling

    Yi Wang et al.
    Cells in tendon sheaths, considered to be extrinsic tissues of tendon, possess stem or progenitor cell properties that are involved in tendon repair by activating the Hh-TGFb/Smad3 axis.

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