Browse the search results

Page 2 of 366
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley, Guy B Blanchard ... Bénédicte Sanson
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Cancer Biology
    2. Cell Biology

    SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells

    Linda Zhang, Joanne I Hsu ... Margaret A Goodell
    PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.
    1. Neuroscience
    2. Plant Biology

    Hawkmoths evaluate scenting flowers with the tip of their proboscis

    Alexander Haverkamp, Felipe Yon ... Danny Kessler
    Building on previous work (Kessler et al., 2015), it is shown that long-tongued hawkmoths assess individual flowers by smelling floral odors with olfactory neurons on their proboscises, and that this close-range perception is crucial for successful pollination and foraging.
    1. Neuroscience

    Population response magnitude variation in inferotemporal cortex predicts image memorability

    Andrew Jaegle, Vahid Mehrpour ... Nicole Rust
    Population response magnitude predicts how well an image will be remembered, in both monkey inferotemporal cortex and neural networks trained to categorize objects.
    1. Neuroscience

    Brain signatures of a multiscale process of sequence learning in humans

    Maxime Maheu, Stanislas Dehaene, Florent Meyniel
    Evidence for multiple brain systems for sequence processing involving statistical inferences at multiple scales.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

    Liza Dahal, Thomas GW Graham ... Xavier Darzacq
    Type II nuclear receptors do not always compete for a limiting pool of their obligate partner RXRa.
    1. Neuroscience

    Impaired adaptation of learning to contingency volatility in internalizing psychopathology

    Christopher Gagne, Ondrej Zika ... Sonia J Bishop
    Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
    1. Cancer Biology
    2. Genetics and Genomics

    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

    Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz ... Pau Castel
    Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
    1. Cell Biology
    2. Neuroscience

    Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells

    Andrea McQuate, Sharmon Knecht, David W Raible
    The highly metabolically active hair cells of the zebrafish lateral line have a distinct mitochondrial phenotype consisting of small mitochondria apically and large, networked mitochondrion basally, demonstrating a nonuniform mitochondrial architecture that is sculpted by cellular activity.
    1. Stem Cells and Regenerative Medicine

    Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

    Mami Matsuo-Takasaki, Sho Kambayashi ... Yohei Hayashi
    Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.