Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.

An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.

A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.

The discovery of a gene that regulates two segmentation mechanisms in spider embryos is fueling the ongoing debate about the evolution of this crucial developmental process.

Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.