A commonly used immunoglobulin loci-transgenic mouse, the Kymouse, has B cells that go through complete development and have receptor repertoires that show key differences in encoding gene frequencies but structural similarity in their most variable regions.

Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.

A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.

Naturally short-lived turquoise killifish undergo systemic and mucosal spontaneous decline in antibody-repertoire diversity during aging, recapitulating in a few months the aging-dependent decline of adaptive immunity.

The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.

Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.

IgH repertoires of physically sorted and bioinformatically selected B cell subpopulations overlap and are characterised by distinct repertoire characteristics, while certain repertoire features correlate with the position of the constant region on the IgH locus.

Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.

High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.

A comprehensive map of patterns of class switching reveals how antibodies of every class are created in humans.