230 results found
    1. Genes and Chromosomes

    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

    Amy E Campbell et al.
    CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology

    Yu Fu et al.
    The genome sequence of Trichoplusia ni enables the use of this widespread lepidopteran pest as a model for both the study of small RNA pathways and insecticide resistance.
    1. Neuroscience

    The control of tonic pain by active relief learning

    Suyi Zhang et al.
    The brain has a central cortico-striatal learning circuit that suppresses ongoing pain after injury when actively learning about things that could remove the cause of the pain.
    1. Neuroscience

    Single-exposure visual memory judgments are reflected in inferotemporal cortex

    Travis Meyer, Nicole Rust
    In response to the question "Have you seen this image before?", remembering and forgetting can be accounted for by a weighted linear read-out of memory signals in monkey inferotemporal cortex.
    1. Neuroscience

    Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

    Matthieu Raveau et al.
    CA1 physiology is altered in the hippocampus of Down syndrome mice during both spatial exploration and rest, paralleled by an increase in populations of interneurons responsible for single cell and network synchronization.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations

    Jérémie Lefebvre et al.
    Stochastic resonance, triggered by fluctuations in brain state, is found to determine the outcomes of periodic stimulation and how it interacts with brain oscillations.
    1. Neuroscience

    Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

    Weijian Yang et al.
    An all-optical 3D two-photon imaging and photostimulation platform was demonstrated, with the capability to precisely stimulate a large group of cells in mice cortex in vivo with low laser power.
    1. Neuroscience

    A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex

    Richard Hakim et al.
    A neural circuit between layer 2/3 pyramidal cells and somatostatin-expressing inhibitory neurons synchronizes spatially separated regions of the visual cortex to gamma rhythms.
    1. Human Biology and Medicine
    2. Neuroscience

    Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    Roxanne Lofredi et al.
    Bradykinesia in Parkinson's disease may be associated to a dopamine-dependent recruitment failure of subthalamic activity in short bursts of gamma synchrony.
    1. Genes and Chromosomes

    Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

    Juan Manuel Povedano et al.
    Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.

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