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    1. Stem Cells and Regenerative Medicine

    Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

    Kevin L Lu et al.
    rDNA copy number is shown to dynamically change during aging and through generations, and is actively maintained in male germline of Drosophila.
    1. Chromosomes and Gene Expression

    Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

    Bin-zhong Li et al.
    Genetic analysis combined with whole genome sequencing elucidates mechanisms and pathways that form and prevent a specific class of genome rearrangements, foldback inversions, seen in many human cancers.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male wing dimorphism

    Binshuang Li et al.
    The application of long-read sequencing to the pea aphid wing dimorphism system reveals genomic structural divergence as a genetic mechanism of adaptation.
    1. Genetics and Genomics
    2. Plant Biology

    Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting

    Daniela Pignatta et al.
    Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.
    1. Genetics and Genomics

    Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements

    Christopher E Ellison, Doris Bachtrog
    Fully functional regulatory elements can arise rapidly from transposable elements via a novel route where non-allelic gene conversion can act to speed up the evolutionary fine-tuning of regulatory elements.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long et al.
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Chromosomes and Gene Expression

    Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

    Oscar Velazquez Camacho et al.
    An RNA-mediated mechanism that stabilizes association of the Suv39h enzymes at mouse heterochromatin is defined.
    1. Chromosomes and Gene Expression

    Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

    Jiyong Wang et al.
    Redundant pathways prevent heterochromatin spreading and ectopic heterochromatin assembly; and plasticity of heterochromatin assembly allows cells to adapt to heterochromatin stress.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan et al.
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Computational and Systems Biology

    Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies

    Ye Zheng et al.
    A statistical model rescues multi-mapping reads with high accuracy and demonstrates their impact in all facets of the analysis of genome-wide high throughput conformation capture datasets.