962 results found
    1. Microbiology and Infectious Disease

    Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

    Philip V'kovski et al.
    The molecular microenvironment of coronaviral replicase complexes provides functional and spatial links between conserved cellular processes and viral RNA synthesis, and highlights potential targets for the development of novel antivirals.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.
    1. Cell Biology

    Intermediate Filaments: The sweet side of vimentin

    Natasha T Snider et al.
    A protein modification called O-linked glycosylation regulates the interactions between vimentin molecules under normal conditions, and the ability of Chlamydia bacteria to replicate after they infect cells.
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    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T-cell Immunology: The maths of memory

    Jose Borghans, Ruy M Ribeiro
    Mathematical modeling reveals that long-term immunological memory is maintained in a manner that is even more dynamic than previously thought.
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    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

    Mark S Ladinsky et al.
    Large-volume light microscopy combined with higher-resolution electron tomography revealed the spatial distribution of virus-producing cells and highlighted mechanisms of HIV-1 dissemination in bone marrow from a small animal model.

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