4,140 results found
    1. Cancer Biology

    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

    Bente Benedict et al.
    During tumorigenesis loss of p53 not only abrogates cell cycle arrest and apoptosis, but also suppresses the induction of replication-stress-induced DNA double-stranded breaks.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

    Lotte P Watts et al.
    The RIF1-long and short splice variants show distinct ability to protect cells from replication stress by promoting 53BP1 nuclear bodies, representing the first described functional difference between the two variants.
    1. Cell Biology

    ATR expands embryonic stem cell fate potential in response to replication stress

    Sina Atashpaz et al.
    ATR protects stem cell genomes by activating a transcriptional response mediated by totipotency genes, conferring trophoblast differentiation potential, the derepression of which in somatic cells might favour cancer features emergence.
    1. Chromosomes and Gene Expression

    Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

    Rajesh K Yadav et al.
    Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

    Marco Fumasoni, Andrew W Murray
    Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
    1. Chromosomes and Gene Expression

    Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

    Peter Tonzi et al.
    Translesion polymerase kappa promotes replication fork restart to maintain genome stability during conditions of nucleotide deprivation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

    Tom Killelea et al.
    An investigation into 8-oxodeoxguanosine bypass by archaeal DNA polymerases.
    1. Stem Cells and Regenerative Medicine

    Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

    Nicola Alessio et al.
    Protein IGFBP-4 acts as a genotoxic stress mediator that, entering into circulation after its secretion by senescent cells, could promote further senescence phenomena in non-injured cells thus impairing tissues’ homeostasis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

    Sarah R Hengel et al.
    Small molecule inhibitors identified in a biophysical high-throughout screening assay confirm the importance of the interaction between single-stranded DNA and the protein RAD52 for the survival of BRCA2-depleted cells.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.

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