2,903 results found
    1. Chromosomes and Gene Expression

    Dual control of NAD+ synthesis by purine metabolites in yeast

    Benoît Pinson et al.
    Two distinct processes drive coordinated synthesis of purine and pyridine (NAD+) nucleotides in response to AICAR derivatives and ATP.
    1. Neuroscience

    Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila

    Ugur Dag et al.
    Consolidation of long-term courtship memory in Drosophila is mediated by a novel class of sleep promoting neurons that reactivates dopaminergic neurons engaged earlier in memory acquisition during post-learning sleep.
    1. Cancer Biology

    Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

    Blake Ferguson et al.
    Genetic variation determines whether or not UV exposure accelerates melanoma development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail et al.
    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
    1. Cancer Biology

    Melanoma: Accelerating cancer without mutations

    Douglas E Brash
    Mice get melanoma faster when they have common, inherited variants in a few genes that control cell-wide changes but also respond to the environment.
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    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray et al.
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Long-term balancing selection drives evolution of immunity genes in Capsella

    Daniel Koenig et al.
    Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Structural Biology and Molecular Biophysics

    Automated cryo-EM structure refinement using correlation-driven molecular dynamics

    Maxim Igaev et al.
    Correlation-driven molecular dynamics provides a fully automated and human-bias-free framework for quantitative interpretation of modern cryo-electron microscopy data.
    1. Cell Biology
    2. Genetics and Genomics

    Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

    Martin Wegner et al.
    Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.

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