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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

    Jean-Michel Arbona et al.
    The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
    1. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey et al.
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Cancer Biology

    Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

    Christine Mantis et al.
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Microbiology and Infectious Disease

    Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

    Michael B Schulte et al.
    A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
    1. Cancer Biology

    Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Chromosomes and Gene Expression

    p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

    Sunetra Roy et al.
    p53 suppresses genome instability by direct role at stalled replication forks for pathway regulation that explains transcription-independent p53 tumor-suppressor functions.
    1. Cancer Biology

    Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data

    Irawati Kandela et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Cancer Biology

    Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

    Stephen K Horrigan et al.
    Editors' Summary: The results in this Replication Study could not be interpreted.
    1. Cancer Biology
    2. Biochemistry and Chemical Biology

    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

    L Michelle Lewis et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.