183 results found
    1. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey et al.
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Chromosomes and Gene Expression

    Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

    Zheng Hu et al.
    Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold et al.
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Cell Biology

    DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

    Matthew M Crane et al.
    Activation of a DNA-damage cell cycle checkpoint during aging causes genome instability and senescence in yeast mother cells.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Protein biogenesis machinery is a driver of replicative aging in yeast

    Georges E Janssens et al.
    A comprehensive mapping of the proteome and transcriptome during the complete replicative lifespan of budding yeast predicted an increased abundance of the protein biogenesis machinery is most causal for aging.
    1. Cell Biology
    2. Computational and Systems Biology

    Nonlinear feedback drives homeostatic plasticity in H2O2 stress response

    Youlian Goulev et al.
    Nonlinear H2O2 scavenging by peroxiredoxins drives acquired stress resistance and replicative lifespan hormesis.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Life Expectancy: Advancing the aging biology toolkit

    Troy K Coody, Adam L Hughes
    A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research.
    Insight
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    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Temporal profiling of redox-dependent heterogeneity in single cells

    Meytal Radzinski et al.
    Analysis of aging yeast cells using the in-vivo roGFP2-based probe reveals redox-dependent heterogeneity, reflected in a bi-modal distribution of the oxidation status, differential growth and replication, as well as distinct proteomic and transcriptomic profiles.

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