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    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Genetics and Genomics

    Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

    Mohammad Alfatah, Jolyn Jia Jia Lim ... Frank Eisenhaber
    Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.
    1. Chromosomes and Gene Expression

    A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

    Kamil Pabis, Diogo Barardo ... Brian K Kennedy
    A majority of transcribed transposons during aging are derived from transcriptional defects, most notably intron retention and transcriptional readthrough.
    1. Cell Biology

    Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

    Juan Long, Meng Ma ... Jing Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Inadequate
    1. Stem Cells and Regenerative Medicine

    Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype

    Qinyu Zhang, Rasmus Olofzon ... David Bryder
    Application of a polyvinyl alcohol-based culture system reveals extensive differentiation but simultaneous robust murine hematopoietic stem cell (HSC) expansion, which are characterized by phenotypic, functional, and molecular properties shared with freshly isolated bone marrow HSCs.
    1. Microbiology and Infectious Disease

    Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    Nikol Kadeřábková, R. Christopher D. Furniss ... Despoina A.I. Mavridou
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

    Sagen Flowers, Rushali Kothari ... Joel H Rothman
    Mitochondrial quality control in the germline is mediated by regulators of both programmed cell death and the aging program.
    1. Medicine

    PYCR1 Levels Track with Premature and Chronological Skin Aging

    Kortessa Sotiropoulou, Saniye Yumlu ... Bruno Reversade
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Developmental Biology

    Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

    Martina Rossi, Carlos Anerillas ... Myriam Gorospe
    The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.
    1. Genetics and Genomics

    The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

    Monica Sanchez-Contreras, Mariya T Sweetwyne ... Scott R Kennedy
    The accumulation of somatic mutations during aging is not uniform across tissue types and, in addition, shows significant variability in the source of mutation that can be modified by small molecule interventions.
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