10,864 results found
    1. Chromosomes and Gene Expression

    Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

    Wanqing Shao et al.
    Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Plant Biology

    Building customizable auto-luminescent luciferase-based reporters in plants

    Arjun Khakhar et al.
    A fungal bioluminescence pathway can be reconstituted in planta to create luminescence in many plant species without external substrate addition, and be used to design customizable reporters of gene-expression.
    1. Neuroscience

    A new no-report paradigm reveals that face cells encode both consciously perceived and suppressed stimuli

    Janis Karan Hesse, Doris Y Tsao
    Conscious visual percepts are encoded by face patches in the absence of report, can be decoded from population recordings, and are multiplexed with the veridical physical stimulus.
  1. Meta-Research: Large-scale language analysis of peer review reports

    Ivan Buljan et al.
    The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.
    1. Biochemistry and Chemical Biology

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Matthew E Cockman et al.
    Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes

    Joan Comenge et al.
    Combined cell labelling with a bi-cistronic reporter-gene vector and gold nanorods enables short- and long-term cell tracking in vivo via multimodal imaging (multispectral optoacoustic tomography, bioluminescence, fluorescence) with high spatial resolution.
    1. Cancer Biology

    Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

    Hao Zhang et al.
    The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
    1. Cancer Biology
    2. Developmental Biology

    Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

    Shaina N Porter et al.
    Age-specific transcriptional responses to Flt3-ITD and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult, but not fetal/neonatal, stages of development.
    1. Cancer Biology
    2. Cell Biology

    One reporter for in-cell activity profiling of majority of protein kinase oncogenes

    Iva Gudernova et al.
    A new luciferase and fluorescent reporter system enables rapid and efficient in-cell profiling of the majority of protein kinase oncogenes known to date.

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