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Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice
Ashley L Juavinett et al.
A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion
Anett Dunai et al.
Drug-resistance declines in the laboratory in an antibiotic stress-free environment, indicating that restricting antimicrobial usage in the clinics could be a useful policy.
Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T
Kevin R Sitek et al.
MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
Stem Cells and Regenerative Medicine
Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish
Shuguang Yu, Jie He
The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
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Microbiology and Infectious Disease
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
Ting Pan et al.
USP49 can increase A3G protein expression and enhance its anti-HIV-1 activity, which is also correlated with hypermutations and affects the HIV-1 latent reservoir.
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells
Shaheen Kabir et al.
Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
Brian 2, an intuitive and efficient neural simulator
Marcel Stimberg et al.
Biochemistry and Chemical Biology
Computational and Systems Biology
membrane protein interactome captured in Peptidisc libraries
Michael Luke Carlson et al.
Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
Genetics and Genomics
Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in
Evan Witt et al.
Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.
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