710 results found
  1. Episode 42: eLife at five

    In this special episode, we hear about photosynthesis, forensics, peer review, and the past, present and future of eLife.
  2. Meta-research

    Meta-Research: A Collection of Articles

    Curated by Peter Rodgers
    The study of science itself is a growing field of research.
  3. Episode 43: November 2017

    In this episode, we hear about tool use in monkeys, sleep regulation, marsupial placentas, health campaigns and why science papers are so hard to read.
  4. Moving On: eLife at Five

    Curated by Emma Pewsey
    To celebrate five years of eLife we catch up with some of our first authors and reflect on the current state of scientific publishing and peer review.
  5. A syringe injecting a clear liquid into the Earth

    Episode 56: April 2019

    In this episode, we hear about multipartite viruses, brain maps of people without hands, measles vaccinations, reproducible science, and how to spot premature babies.
    1. Developmental Biology
    2. Neuroscience

    Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification

    Esteban Hoijman et al.
    Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Cell Biology

    Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

    Jessica T Chang et al.
    Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al.
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.

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