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  1. In Publishing: The latest on the open-source publishing platform Libero

    An update on the development of eLife’s publishing suite, what’s next, and how publishers, libraries and developers can get involved.
    1. Cancer Biology

    Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

    Blake Ferguson et al.
    Genetic variation determines whether or not UV exposure accelerates melanoma development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Long-term balancing selection drives evolution of immunity genes in Capsella

    Daniel Koenig et al.
    Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Cell Biology
    2. Genetics and Genomics

    Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

    Martin Wegner et al.
    Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy et al.
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Microbiology and Infectious Disease

    Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

    Efraín E Rivera-Serrano et al.
    Quasi-enveloped hepatitis A virions undergo clathrin-mediated endocytosis, followed by ALIX-dependent trafficking to lysosomes where the quasi-envelope is degraded, triggering uncoating of the RNA genome in association with lysosomal membrane rupture.
    1. Structural Biology and Molecular Biophysics

    Architectural principles for Hfq/Crc-mediated regulation of gene expression

    Xue Yuan Pei et al.
    Structural insights show how RNA chaperones cooperate to recognise defined target transcripts and suppress gene expression.
    1. Cell Biology
    2. Neuroscience

    The SNAP-25 linker supports fusion intermediates by local lipid interactions

    Ahmed Shaaban et al.
    The SNAP-25 linker acts as a functional component of SNARE complexes, initially facilitating SNARE interactions and later promoting fusion triggering and pore evolution by local membrane contacts.