101 results found
    1. Evolutionary Biology
    2. Physics of Living Systems

    Evolution of irreversible somatic differentiation

    Yuanxiao Gao et al.
    Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.
    1. Developmental Biology

    Y chromosome functions in mammalian spermatogenesis

    Jeremie Subrini, James Turner
    The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.
    1. Neuroscience

    Diverse inhibitory projections from the cerebellar interposed nucleus

    Elena N Judd et al.
    Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
    1. Neuroscience

    Temporo-cerebellar connectivity underlies timing constraints in audition

    Anika Stockert et al.
    With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
    1. Ecology
    2. Evolutionary Biology

    The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics

    Rene Niehus et al.
    Evolutionary game theory identifies reciprocation as a key winning strategy for warring bacteria.
    1. Cell Biology

    Science Forum: Vision, challenges and opportunities for a Plant Cell Atlas

    Plant Cell Atlas Consortium et al.
    A Plant Cell Atlas that shows the location and organization of molecules at cellular and tissue levels could have far-reaching consequences for plant sciences.
    1. Cell Biology
    2. Genetics and Genomics

    An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development

    Courtney M Schroeder et al.
    Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.
    1. Evolutionary Biology

    Rampant tooth loss across 200 million years of frog evolution

    Daniel J Paluh et al.
    Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Channel nuclear pore complex subunits are required for transposon silencing in Drosophila

    Marzia Munafò et al.
    By linking export and licensing of a piRNA precursor transcript, channel nuclear pore complex subunits Nup54 and Nup58 are specifically required to silence transposons in the Drosophila ovary.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural determinants of voltage-gating properties in calcium channels

    Monica L Fernández-Quintero et al.
    Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.

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