Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
Heather E Machado, Alan O Bergland ... Dmitri A Petrov
Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.
Genetic experiments in zebrafish identify neuropeptide VF (NPVF) signaling and NPVF-expressing neurons as a novel vertebrate hypothalamic sleep-promoting system that is functionally conserved with invertebrates.
Felipe Martelli, Natalia H Hernandes ... Hugo J Bellen
The organic insecticide spinosad severely impacts metabolism, the cell biology, and the visual system of the model insect Drosophila, suggesting that it poses a threat to other non-pest insect exposed to it in the field.
Félix Ramos-León, Matthew J Bush ... Susan Schlimpert
Identification of a novel regulator that directly influences the assembly and function of the cell division machinery in industrially and medically important bacteria.
Natalia Felipe-Medina, Sandrine Caburet ... Alberto M Pendás
Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.
Martin H Fabry, Federica A Falconio ... Gregory J Hannon
Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
Nikos Stratakis, Alexandros P Siskos ... Leda Chatzi
Urinary metabolic signatures relate to adherence to the Mediterranean diet and ultra-processed food intake in childhood and reflect associations of these diet quality indicators with metabolic health.