717 results found
    1. Medicine
    2. Microbiology and Infectious Disease

    HIV-1 DNA predicts disease progression and post-treatment virological control

    James P Williams, Jacob Hurst ... John Frater
    Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Ecology
    2. Evolutionary Biology

    Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila

    Heather E Machado, Alan O Bergland ... Dmitri A Petrov
    Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.
    1. Neuroscience

    Genetic and neuronal regulation of sleep by neuropeptide VF

    Daniel A Lee, Andrey Andreev ... David A Prober
    Genetic experiments in zebrafish identify neuropeptide VF (NPVF) signaling and NPVF-expressing neurons as a novel vertebrate hypothalamic sleep-promoting system that is functionally conserved with invertebrates.
    1. Neuroscience

    Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

    Felipe Martelli, Natalia H Hernandes ... Hugo J Bellen
    The organic insecticide spinosad severely impacts metabolism, the cell biology, and the visual system of the model insect Drosophila, suggesting that it poses a threat to other non-pest insect exposed to it in the field.
    1. Microbiology and Infectious Disease

    A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria

    Félix Ramos-León, Matthew J Bush ... Susan Schlimpert
    Identification of a novel regulator that directly influences the assembly and function of the cell division machinery in industrially and medically important bacteria.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina, Sandrine Caburet ... Alberto M Pendás
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Neuroscience

    C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity

    Tsung-Yuan Hsu, Bo Zhang ... Bi-Tzen Juang
    The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

    Martin H Fabry, Federica A Falconio ... Gregory J Hannon
    Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
    1. Epidemiology and Global Health

    Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

    Nikos Stratakis, Alexandros P Siskos ... Leda Chatzi
    Urinary metabolic signatures relate to adherence to the Mediterranean diet and ultra-processed food intake in childhood and reflect associations of these diet quality indicators with metabolic health.

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