Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
Sarah De Beuckeleer, Tim Van De Looverbosch ... Winnok H De Vos
Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.
Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.
Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
