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    1. Cell Biology
    2. Genes and Chromosomes

    Parasites: Do trypanosome turncoats wait before they commit?

    Cher-Pheng Ooi, Gloria Rudenko
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    1. Plant Biology

    Spontaneous symbiotic reprogramming of plant roots triggered by receptor-like kinases

    Martina Katharina Ried et al.
    Ectopic expression of Symbiosis Receptor-like Kinase (SYMRK) in roots of the legume Lotus japonicus resulted in spontaneous activation of nodule organogenesis and mycorrhiza-related gene expression in the absence of microbial symbionts or signalling molecules.
    1. Developmental Biology and Stem Cells
    2. Immunology and Inflammation

    The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells

    Florian Mair et al.
    Thymic stromal cells help to develop and shape the gamma delta T cell pool.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Cell Biology
    2. Genes and Chromosomes

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram et al.
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Developmental Biology and Stem Cells

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong et al.
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin et al.
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.